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The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle

Ann Intern Med 158(1):19 Lavonas EJ, Drennan IR, Gabrielli A, Heffner AC, Hoyte CO, Orkin AM, Sawyer KN, Donnino MW (2015) Part 10: special circumstances of resuscitation: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care

In turn, the receptor phosphorylation promotes STATs phosphorylation and dissociation from the GHR as well as the dimerization and translocation to the nucleus, where it activates specific transcription elements on DNA and regulates the transcription of different genes, including IGF-1 ( Figure 1 )

doi:10.1016/j.ijdevneu.2007.08.004 Stefanello FM, Matte C, Pederzolli CD, Kolling J, Mescka CP, Lamers ML, de Assis AM, Perry ML, dos Santos MF, Dutra CS, Wyse ATS (2009) Hypermethioninemia provokes oxidative damage and histological changes in liver of rats