glutathione intramuscular dosage Injections: Uses, Benefits, & Side Effects Explained Glutathione Injections, Anti-Oxidant Treatment |

USA 108 , 1812618131 (2011)

The primary long-term concern is cofactor depletion glutathione relies on zinc and selenium for its antioxidant enzyme systems, and prolonged high-dose use (beyond 12 weeks) can deplete these minerals, potentially causing fatigue or immune suppression

If the glutathione redox balance shifts towards the oxidized forms, it could serve as a precursor for DNA damage and possibly increased apoptosis, playing a crucial role as one of the causes of the disorder (Kulkarni and Wilson, 2008

The proposed mechanism for the cause of favism is that these new compounds then undergo redox cycling and in the process deplete reduced glutathione, leading to the formation of free radicals and hydrogen peroxide that damage red blood cells in individuals deficient in G6PD