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Ichimura et al., 2000)

Distant metastases form monophyletic groups and have reduced clonality compared to LN metastases, suggesting different evolutionary mechanisms between LN metastases and distant metastases (154)

In addition to TET enzymes, VitC enhances the activity of Jumonji C (JmjC) domain-containing histone demethylases (JHDM) and thereby hinders the aberrant self-renewal of hematopoietic stem cells [3]