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As a retrospective analysis of electronic health records, it is susceptible to selection and ascertainment bias, and cardiovascular conditions and outcomes were identified primarily using ICD diagnostic codes, which may not always reflect specialist-confirmed diagnoses

On the basis of the expanding volume of currently emerging research, we have summarized several relevant targets and signaling pathways of UC, including the PI3K/AKT, NF-B, and Wnt/-catenin pathways, as well as the contributions of lncRNAs and miRNAs, endoplasmic reticulum stress, mitochondrial dysfunction, mesenchymal stem cells, macrophage polarization, the gut microbiota, and many other targets and pathways (Table 2)

However, some people, especially those with specific genetic mutations, might not absorb it as efficiently