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Using orthotopic murine breast cancer and melanoma that develop spontaneous LN metastases, we also showed that resection of TDLNs did not prevent ICB responses ( Tumor-derived secreted factors preferentially drain to lymphatic vessels before dilution in the blood

Mechanisms and biomarkers of liver regeneration after drug-induced liver injury

Nevertheless, it remains unclear whether cystine starvation in the TME triggers T-cell ferroptosis and impairs anti-tumor immunity

Conversely, iron deprivation favors polarization toward the M1 phenotype, characterized by enhanced production of pro-inflammatory cytokines and increased capacity to phagocytose and kill tumor cells [83]