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Investigational peptides: Some peptides have promising mechanisms or early studies but are not approved for routine clinical use

16 weeks ~20 syringes 1 tirz/week from Week 1

4 weeks 28 tablets 1 tablet per day x 28 days 8 weeks 56 tablets 1 tablet per day x 56 days 12 weeks 84 tablets 1 tablet per day x 84 days 24 weeks 168 tablets Matches the 24-week Phase 2/Phase 3 treatment window Tablets at 0.25 mg daily (half a 0.5 mg tablet, or one 0.25 mg tablet) Supplier tablets are commonly scored at 0.5 mg

The group receiving a 0.3 mg dose experienced a 6.0% weight loss, with 0.6 mg there was a 6.8% weight loss, with 1.2 mg there was a 9.1% weight loss, with 2.4 mg there was a 9.7% weight loss, and weigh 4.5 mg there was a 10.8% weight loss, compared with 3.0% weight loss for pooled placebo