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And that's true at physiological levels

Wei T, Wang X, Lang K, Song Y, Luo J, Gu Z, et al

ICIs work by blocking the interactions between immune checkpoints such as CTL-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), and programmed cell death ligand-1 (PD-L1) and their ligands, which releases the inhibitory brakes of T cells and results in the robust activation of immune responses (Fig