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Preferably, the optical pure compound of formula (II) is (+) -methyl -6 - methoxy -2 - naphthyl chloride, the solvent is acetonitrile, and the concentration of the solution is 1-10mg/ml

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TLR2/4-signaling can be activated by hyaluronan fragments of distinct sizes which usually interact with CD44, a receptor for hyaluronic acid and other ligands, such as collagens, and MMPs (171, 172)