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Generally, we should not expect to achieve significant benefits with pharmacological treatment if drugs from 3 different groups with different action mechanisms have already been tried, whether alone or in combination, at suitable doses and for a maximum period of 3 months per drug to establish their ineffectiveness

63 Stem cells encapsulated in a hyaluronic acid hydrogel filled the negative mold, and the resulting tissue was cultured for up to 12 weeks in vitro, exhibiting excellent viability and shape retention

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Similar results were obtained using proteinase K digestion of proIGF-1Ea (Supplementary Fig