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Abbreviations ApoE: atherosclerosis-prone apolipoprotein E-deficient ALDH2: Aldehyde dehydrogenase 2 Bax: bcl-2-associated X protein Bcl-2: B-cell lymphoma 2 BMD: Bone mineral density BMI: Body mass index BSP: Bone sialoprotein CBD: cannabidiol COL1: Type 1 collagen E-cig: electronic cigarette GRP55: G protein-coupled receptor 55 MMP: Matrix metalloproteinase NF-B: nuclear factor kappa-light-chain-enhancer of activated B cells NHBE: normal human bronchial epithelial OPG: osteoprotegerin PGE2: Prostaglandin E2 RANK-L: Receptor activator of nuclear factor kappa beta ROS: reactive oxygen species RUNX2: Runt-related transcription factor 2 TIMP: Tissue inhibitors of metalloproteinase References Patel RA, Wilson RF, Patel PA, Palmer RM