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they are suited to isolated focal defects with intact surrounding cartilage, not to the diffuse wear pattern that defines KL Grade III/IV osteoarthritis

Key points Ammonia accumulates in patients with liver dysfunction owing to its increased production and impaired detoxification by urea cycle enzymes and glutamine synthetase

In addition, there are many compounds that can induce ferroptosis by inhibiting GPX4, like DPI7 and DPI10 in a directing binding manner and FIN56 in a form that induces GPX4 degradation (Mou et al., 2019

In-depth exploration of the metabolic characteristics of tumor cells, coupled with the development of targeted therapies that exploit these specific traits, represents a critical and promising trajectory for future cancer research endeavors (Fig