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10.1007/s00429-023-02718-8 Brain Struct

Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome

When studied together, the effect appears additive rather than redundant

Disruption of FOCM, whether from genetic variation, dietary folate deficiency, hyperhomocysteinemia, or excess methionine, can lead to oxidative stress, impaired DNA methylation, neurotransmitter imbalance, glial activation, and impaired neuronal function