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Physiol Rev 95:513548 Sapru MK, Yates JW, Hogan S, Jiang L, Halter J, Bohn MC (2006) Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi

Clinical Evidence Comparison Cerebrolysin: Extensive Clinical Research Base Cerebrolysin has one of the most extensive clinical research bases of any neurotrophic agent, spanning more than three decades of human studies: Alzheimer's Disease Meta-Analysis: Gauthier et al

Significant gut flora modification was observed in the opioid cohort, especially in encephalopathic patients on opioids with lower abundance of the autochthonous families compared to others (Clostridiales XIV and Lachnospiraceae ) along with a decrease in Bacteroidaceae relative abundance