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[DOI] [PMC free article] [PubMed] [Google Scholar] [60].Baptista MS, Cadet J, Di Mascio P, Ghogare AA, Greer A, Hamblin MR, et al

showed that hypoxia markedly enhances the tenogenic differentiation of adipose-derived mesenchymal stem cells in co-culture with tenocytes by upregulating HIF-1, while HIF-1 inhibition suppresses this response, and FG-4592 mediated stabilization of HIF-1 further amplifies it, identifying HIF-1 as a key driver of adipose-derived mesenchymal stem cell commitment toward a tenocyte lineage (Yu Y