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Description

Central and peripheral nervous system models in rats covering traumatic injury, stroke, and peripheral nerve transection, with cell-survival and tract-tracing endpoints

Strokeprone rats were given either saline or curcumin daily

In the absence of clinical pathological or histopathological effects, the NOAEL for systemic toxicity was 1000 mg/kg bw per day, the highest dose tested (Goldenthal, 1991)