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Alternatively, pre-treatment with SE-EE attenuated the same through a prominent enrichment of the proliferating cells with apparently higher Ki67 positive stained cells, compared to the scopolamine groups

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These include using biodegradable backbones or enzymatically cleavable linkers, surface neutralization (for example hydroxylation, carboxylation or PEGylation) to reduce cationic surface reactivity, minimizing generation/size for dendrimers while preserving targeting, and requiring chronic-dosing safety packages that measure persistent microglial activation and behavioral outcomes before first-in-human trials