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A 5 mg/kg dose in mice converts to a humanequivalent exposure of about 0.4 mg/kg when you apply standard bodysurfacearea scaling (Km mouse 3, Km human 37), so: 5 mg/kg (3/37) 0.4 mg/kg

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Common causes include: Poor dietary intake (common in vegans and vegetarians) Malabsorption disorders (e.g., pernicious anemia, celiac disease, Crohns disease) Certain medications (e.g., metformin, proton pump inhibitors) Aging (reduced stomach acid affects absorption) Alcoholism (impairs absorption) Gastrointestinal surgery (such as gastric bypass or removal of part of the stomach) What is the fastest way to fix B12 deficiency

(2017) also identified serum HGF level as a potential diagnostic