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They have been extensively studied in large-scale human clinical trials, with robust safety data spanning over a decade

European journal of anaesthesiology , 18 7, 419-22

[DOI] [PubMed] [Google Scholar] 187.Hatch HW, Bergonzo C, Blanco MA, Yuan G, Grudinin S, Lund M, Curtis JE, Grishaev AV, Liu Y, Shen VK

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