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Chronic ethanol exposure reduces tryptophan hydroxylase (TPH2) activitythe rate-limiting enzyme in 5-HT synthesisin the dorsal raphe nuclei (DRN) of rodents, leading to depleted 5-HT levels in the prefrontal cortex (PFC) and amygdala

HCC-associated SPOP mutants abrogate the inhibitory effect of SPOP-WT on KCNN3-induced progression in HCC via the CTCF-SATB1 axis To verify the effect of SPOP on KCNN3-induced EMT of HCC, we found that SPOP-WT inhibited KCNN3-induced HCC progression, which was eliminated in the KCNN3-SBC and SPOP-M35L/D153Y groups in vitro (Fig