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A diagnosis of MDD requires five or more of the following symptoms during the same two-week period: Depressed mood most of the day, nearly every day Loss of interest or pleasure in nearly all activities Significant changes in sleep or appetite Fatigue or loss of energy Feelings of worthlessness or excessive guilt Difficulty concentrating or making decisions Thoughts of death or suicide MDD is episodic

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Upon MDV infection, there is a marked upregulation in the expression levels of AvBD2 , AvBD4 , and AvBD7 , while AvBD1 , AvBD6 , and AvBD9 expression levels are significantly downregulated ( Erythrocytes engage complement receptors to enhance the clearance of pathogens