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[1] [2] Neurological protection: Prompt B12 replacement prevents irreversible neurological damage in deficiency states, including subacute combined degeneration of the spinal cord

This progressive deficit leads to insufficient sirtuin activation, mitochondrial respiratory chain dysfunction, and decreased ATP production (Rajman et al., Cell Metab 2018)

We found that Ab68 treatment had effects on fibrosis and body weight comparable to those of dietary supplementation with nicotinamide ribose (NR), a NAD + precursor 24