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In a study with volunteers to unravel the differential contributions of theobromine and caffeine on mood, psychomotor performance, and blood pressure, the authors concluded that caffeine might have more CNS-mediated effects on alertness, while theobromine might be acting primarily via peripheral physiological changes [225]

Medications Certain medications have the unfortunate side-effect of significantly suppressing gut motility and MMC function, which can lead to bacteria and archaea hanging around in the small intestine

Adequate GSH levels help preserve neuronal integrity, while depletion is a hallmark of neurodegenerative diseases such as Parkinsons and Alzheimers (4849)