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Oncogene-mediated ROS production has been associated with (i) Ras-activated signaling altering the metabolism of the mitochondrial potential and increasing the activity of NADPH oxidases 2 and 4 (NOX2 and NOX4), (ii) antiapoptotic B-cell lymphoma 2 (Bcl-2) altering the mitochondrial potential, (iii) signal transducer and activator of transcription 3 (STAT3) altering mitochondrial metabolism and activating NADPH 4 (NOX4), and (iv) the multipurpose oncogenic transcription factor MYC (a cancer of the myelocytes, myelocytoma), which downregulates mitochondrial mass and biogenesis (Hayes et al

It also induced NF-B translocation by TNF and the phosphorylation of IkB kinase-/ and IkB

This can lead to leaky gut, a condition that worsens digestion and nutrient absorption, including B12

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