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Description

Upon entering the cell, MPP+ inhibits the mitochondrial ETC Complex I enzyme, and NADH-ubiquinone oxidoreductase (EC 1.6.5.3), resulting in electron leakage and ROS generation in mitochondria [32]

The eliminating organs, based on the drug's body clearance time, can readily remove the drug with no indication that the eliminating mechanisms are saturated

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Acetyl-L-carnitine (ALCAR), the acetyl ester of L-Carnitine, is endogenously synthesized in human or obtained from dietary sources with a higher bioavailability compared to L-carnitine