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Description

PI3K/AKT activation mediates cell survival and resistance to apoptosis through inactivation of the pro-apoptotic protein BCL-2 antagonist of cell death (BAD) and degradation of the pro-apoptotic protein p53 (Birchmeier et al., 2003)

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The Ames test showed no mutagenicity, chromosomal aberration assays detected no genotoxicity, and micronucleus testing revealed no clastogenic effects

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