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It is reported that with aging, the level of succinate decreases, which can be restored by phytochemical supplementation[65,66]

6.2 Potential pathophysiological mechanisms of gut microbiota and metabolite SCFAs in cytokine abnormalities SCFAs (such as acetate, propionate, and butyrate) activate receptors like FFAR2/3 and Gpr109a and inhibit histone deacetylase (HDAC), collectively suppressing the activation of the NF-B signaling pathway, thereby downregulating the expression of pro-inflammatory cytokines (202204)

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Respondents were aged 1870 years, and they (or the person they cared for) had been diagnosed with NASH by a medical test, had a healthcare professional currently treating them and knew which stage of NASH they were originally diagnosed with and currently in