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An echocardiogram (echo) will be ordered to further evaluate the hearts structure

The statistical significance of the difference between two means assessed twice for the same research group was evaluated using a paired t-test or and Wilcoxon signed-rank test

Interplay between inflammation and neural plasticity: both immune activation and suppression impair LTP and BDNF expression

The M3R is also expressed on brain microvascular endothelium (Radu et al., 2017), and M3R signaling is also important in adaptive immunity and autoimmunity (indeed, M3R is a candidate receptor for autoantigen recognition by T and B cells) (Sumida et al., 2014)