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1 Introduction Colorectal cancer (CRC) remains one of the most prevalent and deadly malignancies worldwide, ranking as the fourth leading cause of cancer-related mortality globally and the second most common cancer in Europe ( Simultaneously, physical exercise, particularly aerobic and resistance training, has emerged as an effective non-pharmacological intervention that can improve CRC patient outcomes ( Emerging research has also highlighted the relevance of the gutbrain axis and neuroimmune signaling in the development and progression of CRC