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For non-normally distributed data, the MannWhitney U test or KruskalWallis test followed by Dunns post hoc test was used

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For instance, Pelizaeus-Merbacher disease is caused by a mutation in the myelin gene PLP1 , which results in the accumulation of cholesterol and membrane raft components in lysosomal compartments due to mistrafficking of these myelin elements 122,123,124,125