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In addition to this molecular regulation, pharmacokinetics is also influenced by circadian variation in physiological processes such as hepatic blood flow, gastrointestinal motility, gastric pH, renal perfusion, and plasma concentration of binding proteins, which vary rhythmically and interfere with the absorption, availability, metabolism, and excretion of drugs

We would further suggest that the approach is invalidated by the violation of a particular requirement of MR studies, i.e

Drug interaction studies with psychiatric medications are essential before any clinical use

The diagnostic efficacy of potential discriminatory biomarkers for PSO was evaluated by ROC curve analysis