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Collectively, combination therapy with anti-VEGFR2 and anti-PD-1 reprograms the immune microenvironment via vessel normalization, further strengthening the anti-cancer immune response and overcoming resistance to cancer immunotherapy in HCC

Supplementary material The Supplementary Material for this article can be found online at: -ECS -Glutamylcysteine synthetase APX Ascorbate peroxidase AsA Ascorbate or ascorbic acid CA Citric acid CB Cyanobacteria CAT Catalase Chl a Chlorophyll a Chl b Chlorophyll b Chl a + b Total chlorophyll DHA Dehydroascorbate DHAR Dehydroxyascorbate reductase EL Electrolyte leakage F v /F m Ratio of variable fluorescence over maximum fluorescence or maximum potential quantum efficiency of Photosystem II Gly I Glyoxalase I Gly II Glyoxalase II GPX Glutathione peroxidase GR Glutathione reductase GSH Glutathione or -glutamyl-cysteinyl-glycine or reduced glutathione GSHS Glutathione synthase GSSG Glutathione disulfide or oxidized glutathione GST Glutathione S-transferase HA Humic acid HM Heavy Metals MDA Malondialdehyde MDHA Monodehydroascorbate MG Methylglyoxal MLE Moringa Leaf Extract MSI Membrane stability index MT Melatonin NADPH Nicotinamide adenine dinucleotide phosphate PA Polyamine PC Phytochelatin PCS Phytochelatin synthase POD Peroxidase Pro Proline Put Putrescine ROS Reactive oxygen species RWC Relative water content Se Selenium SLG S-D-Lactoylglutathione SOD Superoxide dismutase Spd Spermidine Spm Spermine Sub Submergence TCA Tricarboxylic acid Abbreviations References 1 Abd El-MageedT

Instead, this can be explained by which proteins were affected and the direction of their change

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