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Conversely, the EAM mice displayed fragmented and sparse myofibrillar architecture, with rounded mitochondria, loss of inner membrane integrity, fragmented cristae, and swollen matrix

Monzel AS, Enrquez JA, Picard M (2023) Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction

These include smoking, excessive coffee or alcohol consumption, diabetes, rheumatoid arthritis, thyroid disorders, coeliac disease, Crohns disease, obesity, physical inactivity, chronic stress, and certain long term medications such as proton pump inhibitors and corticosteroids