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OMIM #229,300) is an autosomal recessive neurodegenerative disease with a prevalence of approximately 1 in 50,000 individuals, characterized by progressive gait and limb ataxia, sensory loss, muscle weakness, dysarthria, and hypertrophic cardiomyopathy

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However, the major effects are found in the liver where the conversion of glucose into glycogen is promoted, and glucose output is decreased (4)

Sorafenib significantly induces exspression of MT-1G messenger RNA and proteins, and activation of Nrf2 is critical for MT-1G expression induced after sorafenib treatment (Houessinon et al., 2016)