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Notably, a significant decrease in the expression of gnd , which is pivotal for NADPH production and thus essential for maintaining cellular redox homeostasis and GSH levels, was observed in the GR mutant compared to the WT strain (Figure 4A), suggesting that GR knockout leads to important alterations in metabolic processes, particularly carboxyltransferase activity and carbohydrate metabolism, consistent with our earlier observations

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Following sciatic nerve injury, localized mechanical stress and ischaemia-reperfusion rapidly trigger a sterile inflammatory response centred on macrophages and neutrophils 5

It is inhabited by a large number of commensal microorganisms that form colonies, and under healthy conditions pathogenic bacteria cannot outgrow them or penetrate further