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50,51 Recent metabonomics retrospective studies had shown that increased plasma levels of BCAAs are associated with an increased risk of pancreatic cancer, which was validated in a genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC)

J Physiol Paris 95(16):337344 Watanabe K, Konno S, Sekiguchi M, Kikuchi S (2007) Spinal stenosis: assessment of motor function, VEGF expression and angiogenesis in an experimental model in the rat

The levels of OS markers, including protein carbonyls, 4-hydroxy-2-non-enal (HNE), 3-nitrotyrosine (3-NT), and 8-OHdG, are increased in the blood and cerebrospinal fluid of patients with AD (172, 173)

doi: 10.3389/fcimb.2019.00042 Received 17 September 2018 Accepted 08 February 2019 Published 04 March 2019 Volume 9 - 2019 Edited by Saliha Durmu, Gebze Technical University, Turkey Reviewed by Fernando Navarro-Garcia, Centro de Investigacin y de Estudios Avanzados (CINVESTAV), Mexico