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10.1093/jn/133.5.1517S J

The specific mechanisms underlying the positive effects of selenium supplementation as an adjuvant are not fully understood

The most frequently cited open-design results describe reduced cardiovascular and total mortality over six- and fifteen-year follow-up periods in elderly subjects receiving annual courses of pineal- and thymic-peptide preparations, with larger reductions reported in the combined-peptide arms (Anisimov & Khavinson, reviewed in Peptides and Ageing , 2002