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doi: 10.1016/J.BBAMCR.2014.04.017 56 KawiakAKosteckaA

This mechanism has particularly important implications for wound healing research

Activation of SIRT1 has been shown to boost the expression of antioxidant genes by deacetylating and activating Nrf2, subsequently mitigates cell damage caused by oxidative stress and dysregulated iron metabolism

It ensures a steady, continuous stream of hormones for 36 months, avoiding the disruptive fluctuations that cause side effects with other delivery methods