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The progressive neuronal loss, limited treatment efficacy, and enormous social and economic burden underscore the critical importance of early, targeted, and multi-mechanistic neuroprotective approaches

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a , Representative spinal cord images show the distribution of CD8 + T cells (yellow spots), pTau (red), and GZMK (cyan) in the spinal cords of P301S +/+ CD8 WT (n = 5) and P301S +/+ CD8 KO (n = 4) mice at 30 weeks