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Dean DC, Hurley SA, Kecskemeti SR, OGrady JP, Canda C, Davenport-Sis NJ, Carlsson CM, Zetterberg H, Blennow K, Asthana S, Sager MA, Johnson SC, Alexander AL, Bendlin BB (2017) Association of amyloid pathology with myelin alteration in preclinical alzheimer disease

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These include acne, metabolic syndrome (affecting about 40% of patients), insulin resistance, diabetes, hypertension, dyslipidaemia, cardiovascular disease, polycystic ovarian syndrome (PCOS), Crohns disease, pilonidal sinus disease, depression and spondyloarthritis

Mechanisms of Action and Pharmacokinetics The DPP-4 Inhibitors increase the concentration of active incretin hormones, GLP-1, and glucose, which depends on insulinotropic polypeptide (GIP)