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The CRISPR/Cas9 system has gained widespread attention among the various genome-editing methods

Phase II trials showed reduced injury markers during surgery (Orhan et al., 2006) and, notably, a significant reduction in infarct size and improved myocardial salvage when combined with nitrates in acute STEMI patients undergoing primary PCI [NACIAM trial (Pasupathy et al., 2017)], suggesting potential utility in the acute setting, possibly by enhancing endogenous defenses